Peels using beta-hydroxy acid (or BHA) had slightly fewer side effects and results that lasted a bit longer than did peels using alpha-hydroxy acid (or AHA), the study found. But overall, both types of treatments were similarly effective in reducing lesions caused by acne vulgaris, the medical term for common facial acne, which affects some 85 percent of all people 12 to 24 years old.

“This is good news for the millions of Americans who suffer from mild to moderately severe facial acne,” said Dee Anna Glaser, M.D., vice chair and professor of dermatology at the Saint Louis University School of Medicine. “This provides more options for patients and doctors to chose from when it comes to tailoring a treatment program for each individual.”

AHA (which is also called glycolic acid) and BHA (also called salicylic acid) are frequently used by physicians to induce light skin peels, which help treat fine lines and wrinkles, acne and uneven texture and coloration. The peel removes a very thin layer of skin, which in turn promotes the growth of new, smoother skin.

Both types of acid are derived from organic compounds. AHA has the same active ingredient that’s found in sugar cane juice, sour milk and tomato juice, while BHA is derived from salicin, which is closely related to the active ingredient in aspirin.

The study involved 20 patients with moderate to severe facial acne. Their average age was 24 years; 13 were women. Each was treated with a chemical peel every other week for six weeks, with follow-up visits one month and two months after the last treatment.

Each treatment involved applying alpha-hydroxy acid to one side of the face and beta-hydroxy acid to the other side. Neither the patient nor the person who later evaluated them were aware which side of the face had been treated with which acid.

The study found that both types of chemical peels significantly reduced acne lesions within two weeks of the first treatment, and patients continued to see a reduction in lesions through the first follow-up visit a month after the treatments had finished.

At the time of that first post-treatment visit, 94 percent of patients were judged to have had good or fair improvement in acne lesions on both sides of the face, as assessed by a blinded evaluator.

A month later, at the second post-treatment visit, 81 percent of the sides of the face treated with beta-hydroxy acid still showed good or fair improvement in acne lesions, compared with 75 percent of the sides of the face treated with alpha-hydroxy acid. However, the sides of the face treated with alpha-hydroxy acid had developed a few new lesions - though this was judged not to be significant.

In general, both types of acid peels yielded the same side effects, which typically decreased over the course of the treatments. The most common of these included redness, peeling and scaling - though with alpha-hydroxy acid, the degree of the peeling and scaling was judged to be greater.

The research is published in a recent edition of Dermatologic Surgery.

In addition to Glaser, other researchers involved in the study included Katherine Flanagan, M.D., and Edward Kessler of the Saint Louis University of Medicine; Christina Chia, M.D., of the Yale University School of Medicine; and Cynthia Rogers, M.D., of Port Saint Lucie, Fla.

http://www.sciencedaily.com/releases/2008/02/080206121508.htm

[0003] In the search for a safe and effective sebossuppressive agent that could be used topically, applicants screened a number of classes of pharmaceuticals that are commonly in use for various pharmacological activities, including topical antihistamines. Antihistamine drugs or H-1 antagonists are not known to have any effect on the sebaceous gland or the production of sebum.

[0004] Applicants have discovered that certain topical antihistamine preparations typically sold over the counter and used to relieve itching, in particular, diphenhydramine hydrochloride [1-2%] and tripelennamine hydrochloride [0.5-2.0%], when used in various formulations, can be used to reduce generation of sebum, and moreover, once sebum is reduced, subsequent treatment of acne, seborrhea or dermatitis by known conventional methods is more effective and less objectionable to patients so treated.

Eating too much refined bread and cereal may be one of the causes of teenage acne, according to a team of US scientists reports this month’s New Scientist.

A team of researchers led by Loren Cordain, described by the report as ‘an evolutionary biologist’ at Colorado State University in Fort Collins, US, suggest that the highly processed breads and cereals, which have become a staple of the Western diet, lead to the excessive levels of male hormones which cause acne.

The researchers explain that refined grain products are easily digested and the resulting ‘flood of sugars’ makes the body produce large amounts of insulin and insulin-like growth factor (IGF-1), leading to the excessive production of male hormones, according to the report. IGF-1 also encourages skin cells called keratinocytes, a hallmark of acne, to multiply.

The team will publish its findings in the December issue of Archives of Dermatology.

The report notes that almost all 18-year-olds in modern societies suffer from acne, but ’subsistence’ societies such as the Kitava islanders in Papua New Guinea and the Ache of the Amazon rarely see symptoms of the condition. The US researchers believe this is because there are no refined sugars or grains in their diets.

The report explains that modern processing techniques disrupt the protein structures of grains used in refined foods. Digestion is made easier, but the pancreas responds to this by producing high amounts of insulin.

New Scientist adds that an Australian team at RMIT University in Melbourne is to test the theory by studying the effects of a low-carbohydrate diet on boys with acne.

A US patent for the preparation of water soluble salts of lipoic acid was recently issued, after the supplier formulated a method to render it both stable and water soluble. This process greatly increases potential applications.

The salts are said to have anti acne properties and slow down collagenase and elastase enzymes. Sabinsa’s patented version has a potentially wider range of applications.

Source: Clarisse Douaud; Decision News Media SAS

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